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| Elenco delle Pubblicazioni Internazionali |
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Gaetano Santulli, Michele Ciccarelli, Gianluigi Palumbo, Alfonso Campanile, Gennaro Galasso, Barbara Ziaco, Giovanna G Altobelli, Vincenzo Cimini, Federico Piscione, Luca D D'Andrea, Carlo Pedone, Bruno Trimarco, Guido Iaccarino.
In vivo properties of the proangiogenic peptide QK
Journal of Translational Medicine 2009, 7:41
http://www.translational-medicine.com/content/7/1/41
Ersilia Cipolletta, Alfonso Campanile, Gaetano Santulli, Emma Sanzari, Dario Leosco, Pietro Campiglia, Bruno Trimarco, Guido Iaccarino.
The G Protein Receptor Kinase 2 plays an essential role in beta adrenergic receptor induced insulin resistance.
Cardiovasc Res. 2009;
Oriente F, Iovino S, Cassese A, Romano C, Miele C, Troncone G, Balletta M, Perfetti A, Santulli G, Iaccarino G, Valentino R, Beguinot F, Formisano P.
Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.
Diabetologia. 2009 Sep 30. [Epub ahead of print]
Cittadini A, Monti M, Castiello M, D'Arco E, Galasso G, Sorriento D, Saldamarco L, de Paulis A, Napoli R, Iaccarino G, Saccà L.
Insulin-like Growth Factor-1 Protects from Vascular Stenosis and Accelerates Reendothelialization in a Rat Model of Carotid Artery Injury.
J Thromb Haemost. 2009 Sep 9. [Epub ahead of print]
Izzo R, de Simone G, Chinali M, Iaccarino G, Trimarco V, Rozza F, Giudice R, Trimarco B, De Luca N.
Insufficient control of blood pressure and incident diabetes.
Diabetes Care. 2009 May;32(5):845-50. Epub 2009 Feb 17.
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G.
The G-protein-coupled receptor kinase 5 inhibits NFkB transcriptional activity by inducing nuclear accumulation of IkBalpha.
Proc Natl Acad Sci U S A. 2008;195:17818-17823.
Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervèro P, Altobelli GG, Cimini V, Pastore L, Piscione F, Trimarco B, Iaccarino G.
Endothelial Alpha-1 Adrenergic receptors regulate neo-angiogenesis.
Br J Pharm. 2008;153:936-946.
Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.
Piscione F, Iaccarino G, Galasso G, Cipolletta E, Rao MA, Brevetti G, Piccolo R, Trimarco B, Chiariello M.
J Am Coll Cardiol. 2008 Oct 21;52(17):1381-8.
Leosco D, Rengo G, Iaccarino G, Golino L, Marchese M, Fortunato F, Zincarelli C, Sanzari E, Ciccarelli M, Galasso G, Altobelli GG, Conti V, Matrone G, Cimini V, Ferrara N, Filippelli A, Koch WJ, Rengo F.
Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.
Cardiovasc Res. 2008 May 1;78(2):385-94. Epub 2007 Dec 18.
Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervero P, Pastore L, Astone D, Trimarco B, Iaccarino G.
Endothelial beta2 adrenergic signaling to AKT: Role of Gi and SRC.
Cell Signal. 2007 Sep;19(9):1949-55.
Lanni F, Santulli G, Izzo R, Rubattu S, Zanda B, Volpe M, Iaccarino G, Trimarco B.
The PlA1/A2 Polymorphism of GpIIIa and Cerebrovascular Events in Hypertension:Increased Risk of Ischemic Stroke in High Risk Patients.
J Hypertens. 2007 Mar;25(3):551-556.
Leosco D, Rengo G, Iaccarino G, Filippelli A, Lymperopoulos A, Zincarelli C, Fortunato F, Golino L, Marchese M, Esposito G, Rapacciuolo A, Rinaldi B, Ferrara N, Koch WJ, Rengo F.
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1596-603. Epub 2007 Jun 8.
Leosco D, Rengo G, Iaccarino G, Sanzari E, Golino L, De Lisa G, Zincarelli C, Fortunato F, Ciccarelli M, Cimini V, Altobelli GG, Piscione F, Galasso G, Trimarco B, Koch WJ, Rengo F.
Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats.
J Gerontol A Biol Sci Med Sci. 2007 May;62(5):471-80.
Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B.
Beta 2 Adrenergic receptor polymorphism and treatment-induced regression of left ventricular hypertrophy in hypertension.
Clin Pharmacol Ther. 2006 Dec;80(6):633-45.
Iaccarino G, Campanile A, Santulli G, Zuppieri F, Koch WJ.
G protein-coupled Receptor Kinases and hypertension: a review of disease mechanisms.
High Blood Pressure & Cardiovascular Prevention. 2006;13(Issue 4):151-158.
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Stromer H, Sorriento D, Peschle C, Trimarco B, Sacca L, Condorelli G.
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling.
Gene Ther. 2006 Jan;13(1):8-19.
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B.
Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system.
Circ Res. 2005 Nov 25;97(11):1182-9. Epub 2005 Oct 20.
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C.
Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide.
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14215-20. Epub 2005 Sep 26. PMID: 16186493 [PubMed - in process]
De Luca N, Izzo R, Iaccarino G, Malini PL, Morisco C, Rozza F, Iovino GL, Rao MA, Bodenizza C, Lanni F, Guerrera L, Arcucci O, Trimarco B.
The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis.
J Hypertens. 2005 Jul;23(7):1417-1423.PMID: 15942466 [PubMed - as supplied by publisher]
Ferrara N, Abete P, Corbi G, Paolisso G, Longobardi G, Calabrese C, Cacciatore F, Scarpa D, Iaccarino G, Trimarco B, Leosco D, Rengo F.
Insulin-induced changes in beta-adrenergic response: an experimental study in the isolated rat papillary muscle.
Am J Hypertens. 2005 Mar;18(3):348-53.PMID: 15797652 [PubMed - in process]
Barbato E, Piscione F, Bartunek J, Galasso G, Cirillo P, De Luca G, Iaccarino G, De Bruyne B, Chiariello M, Wijns W.
Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries.
Circulation. 2005 Jan 25;111(3):288-94. Epub 2005 Jan 10.PMID: 15642763 [PubMed - in process]
Iaccarino G, Lanni F, Cipolletta E, Trimarco V, Izzo R, Iovino GL, De Luca N, Trimarco B.
The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension.J Hypertens. 2004 Nov;22(11):2117-22.PMID: 15480095 [PubMed - indexed for MEDLINE]
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B.
AKT participates in endothelial dysfunction in hypertension.
Circulation. 2004 Jun 1;109(21):2587-93.
Iaccarino G, Koch WJ.
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.Assay Drug Dev Technol. 2003 Apr;1(2):347-55. Review.PMID: 15090200 [PubMed - indexed for MEDLINE]
Iaccarino G, Koch WJ.
In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis.Methods Mol Biol. 2004;237:181-92. Review.PMID: 14501050 [PubMed - indexed for MEDLINE]
Cittadini A, Isgaard J, Monti MG, Casaburi C, Di Gianni A, Serpico R, Iaccarino G, Sacca L. Growth hormone prolongs survival in experimental postinfarction heart failure.J Am Coll Cardiol. 2003 Jun 18;41(12):2154-63.PMID: 12821240 [PubMed - indexed for MEDLINE]
Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B.
Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries.Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H369-74. Epub 2003 Mar 13.PMID: 12637361 [PubMed - indexed for MEDLINE]
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J Jr.
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12333-8.PMID: 12237475 [PubMed - indexed for MEDLINE]
Iaccarino G, Cipolletta E, Fiorillo A, Annecchiarico M, Ciccarelli M, Cimini V, Koch WJ, Trimarco B. Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension.
Circulation. 2002 Jul 16;106(3):349-55.PMID: 12119252 [PubMed - indexed for MEDLINE]
Iaccarino G, Barbato E, Cipolletta E, Esposito A, Fiorillo A, Koch WJ, Trimarco B.
Cardiac betaARK1 upregulation induced by chronic salt deprivation in rats.
Hypertension. 2001 Aug;38(2):255-60.PMID: 11509486 [PubMed - indexed for MEDLINE]
Iaccarino G, Keys JR, Rapacciuolo A, Shotwell KF, Lefkowitz RJ, Rockman HA, Koch WJ.
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
J Am Coll Cardiol. 2001 Aug;38(2):534-40.PMID: 11499749 [PubMed - indexed for MEDLINE]
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA.
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.J Clin Invest. 2001 Apr;107(8):967-74.PMID: 11306600 [PubMed - indexed for MEDLINE]
Iaccarino G, Barbato E, Cipoletta E, Fiorillo A, Trimarco B.
Role of the sympathetic nervous system in cardiac remodeling in hypertension.Clin Exp Hypertens. 2001 Jan-Feb;23(1-2):35-43. Review.PMID: 11270587 [PubMed - indexed for MEDLINE]
Freeman K, Colon-Rivera C, Olsson MC, Moore RL, Weinberger HD, Grupp IL, Vikstrom KL, Iaccarino G, Koch WJ, Leinwand LA.
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H151-9.PMID: 11123229 [PubMed - indexed for MEDLINE]
Iaccarino G, Koch WJ.
G beta gamma-mediated signaling: new therapeutic target for proliferative vascular disease.IUBMB Life. 1999 Sep;48(3):257-61. Review.PMID: 10690635 [PubMed - indexed for MEDLINE]
Iaccarino G, Lefkowitz RJ, Koch WJ.
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
Proc Assoc Am Physicians. 1999 Sep-Oct;111(5):399-405. Review.PMID: 10519160 [PubMed - indexed for MEDLINE]
Huynh TT, Iaccarino G, Davies MG, Safi HJ, Koch WJ, Hagen PO.
External support modulates G protein expression and receptor coupling in experimental vein grafts.Surgery. 1999 Aug;126(2):127-34.PMID: 10455874 [PubMed - indexed for MEDLINE]
Iaccarino G, Smithwick LA, Lefkowitz RJ, Koch WJ.
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3945-50.PMID: 10097143 [PubMed - indexed for MEDLINE]
Zeiders JL, Seidler FJ, Iaccarino G, Koch WJ, Slotkin TA.
Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling.
J Mol Cell Cardiol. 1999 Feb;31(2):413-23.PMID: 10093053 [PubMed - indexed for MEDLINE]
Iaccarino G, Dolber PC, Lefkowitz RJ, Koch WJ.
Beta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.Hypertension. 1999 Jan;33(1 Pt 2):396-401.PMID: 9931136 [PubMed - indexed for MEDLINE]
Iannuzzi A, Bianciardi G, Faccenda F, Gnasso A, Scarpato N, Di Marino L, Iaccarino G, Simoes C, Sacchi G, Weber E.
Correction of erythrocyte shape abnormalities in familial hypercholesterolemia after LDL-apheresis: does it influence cerebral hemodynamics?
Heart Vessels. 1997;12(5):234-40.PMID: 9846809 [PubMed - indexed for MEDLINE]
Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ.
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Circulation. 1998 Oct 27;98(17):1783-9.PMID: 9788834 [PubMed - indexed for MEDLINE]
Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ.
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.
Am J Physiol. 1998 Oct;275(4 Pt 2):H1298-306.PMID: 9746479 [PubMed - indexed for MEDLINE]
Huynh TT, Iaccarino G, Davies MG, Svendsen E, Koch WJ, Hagen PO.
Adenoviral-mediated inhibition of G beta gamma signaling limits the hyperplastic response in experimental vein grafts.
Surgery. 1998 Aug;124(2):177-86.PMID: 9706136 [PubMed - indexed for MEDLINE]
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J Jr, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7000-5.PMID: 9618528 [PubMed - indexed for MEDLINE]
Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ.
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.Science. 1998 Apr 24;280(5363):574-7.PMID: 9554846 [PubMed - indexed for MEDLINE]
Lembo G, Iaccarino G, Vecchione C, Barbato E, Morisco C, Monti F, Parrella L, Trimarco B.
Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism.Hypertension. 1997 Nov;30(5):1128-34.PMID: 9369266 [PubMed - indexed for MEDLINE]
Lembo G, Iaccarino G, Vecchione C, Barbato E, Izzo R, Fontana D, Trimarco B.
Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm.J Clin Invest. 1997 Oct 15;100(8):2007-14.PMID: 9329964 [PubMed - indexed for MEDLINE]
Volpe M, Iaccarino G, Vecchione C, Rizzoni D, Russo R, Rubattu S, Condorelli G, Ganten U, Ganten D, Trimarco B, Lindpaintner K.
Association and co-segregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.J Clin Invest. 1996 Jul 15;98(2):256-61.PMID: 8755632 [PubMed - indexed for MEDLINE]
Lembo G, Iaccarino G, Vecchione C, Rendina V, Parrella L, Trimarco B.
Insulin modulation of beta-adrenergic vasodilator pathway in human forearm.Circulation. 1996 Apr 1;93(7):1403-10.PMID: 8641030 [PubMed - indexed for MEDLINE]
Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B. Influence of digitalis on left ventricular functional response to exercise in congestive heart failure.Am J Cardiol. 1996 Mar 1;77(7):480-5.PMID: 8629588 [PubMed - indexed for MEDLINE]
Lembo G, Vecchione C, Iaccarino G, Trimarco B. The crosstalk between insulin and the sympathetic nervous system: possible implications in the pathogenesis of essential hypertension.Blood Press Suppl. 1996;1:38-42. Review.PMID: 9162436 [PubMed - indexed for MEDLINE]
Golino P, Ragni M, Cirillo P, Avvedimento VE, Feliciello A, Esposito N, Scognamiglio A, Trimarco B, Iaccarino G, Condorelli M, Chiariello M, Ambrosio G.
Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion.
Nat Med. 1996 Jan;2(1):35-40.
Lembo G, Iaccarino G, Vecchione C, Rendina V, Trimarco B.
Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats.Hypertension. 1995 Aug;26(2):290-3.PMID: 7635537 [PubMed - indexed for MEDLINE]
Rendina V, Iaccarino G, Iovino G, Morisco C, Vecchione C, Trimarco B.
[Non-hemodynamic mechanisms of cardiovascular risk in the hypertensive patient: insulin resistance]Cardiologia. 1994 Dec;39(12 Suppl 1):295-8. Italian.PMID: 7634286 [PubMed - indexed for MEDLINE]
Lembo G, Iaccarino G, Rendina V, Volpe M, Trimarco B.
Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans.Hypertension. 1994 Oct;24(4):429-38.PMID: 7916334 [PubMed - indexed for MEDLINE]
Lembo G, Capaldo B, Rendina V, Iaccarino G, Napoli R, Guida R, Trimarco B, Sacca L.
Acute noradrenergic activation induces insulin resistance in human skeletal muscle.Am J Physiol. 1994 Feb;266(2 Pt 1):E242-7.PMID: 8141282 [PubMed - indexed for MEDLINE]
Rendina V, Iaccarino G, Russo R, Enea J, Marchegiano R, Lembo G, Trimarco B.
Trandolapril in patients with essential hypertension: effects on vascular and cardiac structural changes.
J Cardiovasc Pharmacol. 1994;23 Suppl 1:S20-4.PMID: 7519692 [PubMed - indexed for MEDLINE]
Lembo G, Rendina V, Iaccarino G, Lamenza F, Condorelli G, Rosiello G, Trimarco B.
Insulin does not modulate reflex forearm sympathetic vasoconstriction in patients with essential hypertension.
J Hypertens Suppl. 1993 Dec;11(5):S272-3.PMID: 8158381 [PubMed - indexed for MEDLINE]
Lembo G, Rendina V, Iaccarino G, De Luca N, Ricciardelli B, Volpe M, Trimarco B.
Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy.J Hypertens. 1993 Dec;11(12):1395-402.PMID: 8133021 [PubMed - indexed for MEDLINE]
Lembo G, Rendina V, Iaccarino G, Lamenza F, Volpe M, Trimarco B.
Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans.Hypertension. 1993 Jun;21(6 Pt 2):1015-9.PMID: 8505085 [PubMed - indexed for MEDLINE]
Lembo G, Napoli R, Capaldo B, Rendina V, Iaccarino G, Volpe M, Trimarco B, Sacca L. Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension.J Clin Invest. 1992 Jul;90(1):24-9.PMID: 1634611 [PubMed - indexed for MEDLINE] |
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