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References: N Engl J Med 1998; 338: 65-66 Reviewed: 02/1998

Ibuprofen (analgesic - antipyretic) Drug interactions Interaction with aminoglycosides Four cases of transient acute renal failure after concurrent administration of intravenous ibuprofen and aminoglycoside antibiotics (tobramicin; gentamicin) were described in an article appeared in the New England Journal of Medicine (1998). Patients were aged 2 - 16 years. Aminoglycosides renal toxicity is potentiated by NSAIDs, because the later inhibit the production of renal vasodilating prostaglandins (PGE2) and prostacyclin. This interaction is not described in the italian Summary of Product Characteristics of ibuprofene.

References: Ann Intern Med 1997; 127: 119 Reviewed: 04/1998

Indinavir (antiviral) Urological symptoms HIV patients taking indinavir may experience painful urination or transient renal dysfunction as a result of crystal formation in the urin. This is due to the poor solubility of the drug; a reduced fluid intake can enhance this fenomenon.

References: EPAR: CPMP/590/95 revision 1, nov '97 Reviewed: 03/1998

Interferon-beta (immunomodulating agent) Overdosage The administration of many times the recommended dose for the treatment of Multiple Scerosis did not lead to life-threatening situations.

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