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Metossi Propil Acetato  -MPA-

Scheda di Sicurezza

NIOSH Pocket Guide to Chemical Hazards

n-Propyl acetate CAS 109-60-4
CH3COOCH2CH2CH3 RTECS AJ3675000
Synonyms & Trade Names
Propylacetate, n-Propyl ester of acetic acid		 DOT ID & Guide
1276 129
Exposure
Limits		 NIOSH REL: TWA 200 ppm (840 mg/m3) ST 250 ppm (1050 mg/m3)
OSHA PEL†: TWA 200 ppm (840 mg/m3)
IDLH 1700 ppm See: 109604 Conversion 1 ppm = 4.18 mg/m3
Physical Description
Colorless liquid with a mild, fruity odor.
MW: 102.2
 BP: 215°F
 FRZ: -134°F
 Sol: 2%
VP: 25 mmHg
 IP: 10.04 eV
Sp.Gr: 0.84
Fl.P: 55°F
 UEL: 8%
 LEL(100°F): 1.7%
Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.
Incompatibilities & Reactivities
Nitrates; strong oxidizers, alkalis & acids
Measurement Methods
NIOSH 1450; OSHA 7
See: NMAM or OSHA Methods
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation

 First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations NIOSH/OSHA
Up to 1700 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£/(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)£/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion, skin and/or eye contact
Symptoms In animals: irritation eyes, nose, throat; narcosis; dermatitis
Target Organs Eyes, skin, respiratory system, central nervous system

 

 

n­Propyl acetate

IDLH Documentation

CAS number: 109­60­4

NIOSH REL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

Current OSHA PEL: 200 ppm (840 mg/m3) TWA

1989 OSHA PEL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

1993-1994 ACGIH TLV: 200 ppm (835 mg/m3) TWA, 250 ppm (1,040 mg/m3) STEL

Description of substance: Colorless liquid with a mild, fruity odor.

LEL(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4­hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species Reference LC50

(ppm)

 LCLo

(ppm)

 Time Adjusted 0.5-hr

LC (CF)

 Derived value
Cat Flury & Wirth 1933 ----- 8,941 5 hr 19,223 ppm (2.15) 1,922 ppm
Rat Smyth et al. 1969 LC67: 8,000 ----- 4 hr 16,000 ppm (2.0) 1,600 ppm

Lethal dose data:

Species Reference Route LD50

(mg/kg)

 LDLo

(mg/kg)

 Adjusted LD Derived value
Rat

Mouse

Rabbit

Rat

 Jenner et al. 1964

Jenner et al. 1964

Munch 1972

Smyth et al. 1969

 oral

oral

oral

oral

 9,370

8,300

6,640

8,700

 -----

-----

-----

-----

 15,433 ppm

13,671 ppm

10,936 ppm

14,329 ppm

 1,543 ppm

1,367 ppm

1,094 ppm

1,433 ppm

Other animal data: It has been reported that based on acute inhalation studies, n­propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n­butyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,700 ppm

Basis for revised IDLH: The revised IDLH for n­propyl acetate is 1,700 ppm based on acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth et al. 1969]. The revised IDLH is roughly the same as the revised IDLHs for ethyl acetate and n­butyl acetate and is also 10% of the lower explosive limit of 1.7% (which was determined at 100°F). This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.