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Metossi Propil Acetato  -MPA-

Scheda di Sicurezza

NIOSH Pocket Guide to Chemical Hazards

n-Propyl acetate CAS 109-60-4
Synonyms & Trade Names
Propylacetate, n-Propyl ester of acetic acid
DOT ID & Guide
1276 129
NIOSH REL: TWA 200 ppm (840 mg/m3) ST 250 ppm (1050 mg/m3)
OSHA PEL†: TWA 200 ppm (840 mg/m3)
IDLH 1700 ppm See: 109604 Conversion 1 ppm = 4.18 mg/m3
Physical Description
Colorless liquid with a mild, fruity odor.
MW: 102.2
BP: 215°F
FRZ: -134°F
Sol: 2%
VP: 25 mmHg
IP: 10.04 eV

Sp.Gr: 0.84
Fl.P: 55°F
UEL: 8%
LEL(100°F): 1.7%

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.
Incompatibilities & Reactivities
Nitrates; strong oxidizers, alkalis & acids
Measurement Methods
NIOSH 1450; OSHA 7
See: NMAM or OSHA Methods
Personal Protection & Sanitation
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation

First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations NIOSH/OSHA
Up to 1700 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£/(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)£/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion, skin and/or eye contact
Symptoms In animals: irritation eyes, nose, throat; narcosis; dermatitis
Target Organs Eyes, skin, respiratory system, central nervous system



n­Propyl acetate

IDLH Documentation

CAS number: 109­60­4

NIOSH REL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

Current OSHA PEL: 200 ppm (840 mg/m3) TWA

1989 OSHA PEL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

1993-1994 ACGIH TLV: 200 ppm (835 mg/m3) TWA, 250 ppm (1,040 mg/m3) STEL

Description of substance: Colorless liquid with a mild, fruity odor.

LEL(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4­hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].

Short-term exposure guidelines: None developed


Lethal concentration data:

Species Reference LC50




Time Adjusted 0.5-hr


Derived value
Cat Flury & Wirth 1933 ----- 8,941 5 hr 19,223 ppm (2.15) 1,922 ppm
Rat Smyth et al. 1969 LC67: 8,000 ----- 4 hr 16,000 ppm (2.0) 1,600 ppm

Lethal dose data:

Species Reference Route LD50




Adjusted LD Derived value




Jenner et al. 1964

Jenner et al. 1964

Munch 1972

Smyth et al. 1969













15,433 ppm

13,671 ppm

10,936 ppm

14,329 ppm

1,543 ppm

1,367 ppm

1,094 ppm

1,433 ppm

Other animal data: It has been reported that based on acute inhalation studies, n­propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n­butyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,700 ppm

Basis for revised IDLH: The revised IDLH for n­propyl acetate is 1,700 ppm based on acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth et al. 1969]. The revised IDLH is roughly the same as the revised IDLHs for ethyl acetate and n­butyl acetate and is also 10% of the lower explosive limit of 1.7% (which was determined at 100°F). This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.